Biologics Manufacturer Seeks To Optimize Its Tangential Flow Filtration System To Process More Biomaterial At A Faster Rate.
Case Study: Optimizing Tangential Flow Filtration System for Enhanced Biomaterial Processing
Background
A biologics manufacturer sought to optimize its existing tangential flow filtration (TFF) system to increase the throughput and processing speed of biomaterials. The company faced challenges with high-pressure build-up along the filter and inaccuracies in sensor readings, necessitating an effective upgrade.
Project Overview
To address these issues, the manufacturer collaborated with Agilitech, a provider specializing in single-use solutions. Agilitech was tasked with designing a TFF system that could not only resolve the current issues but also accommodate future scaling needs.
Approach and Solution
- Customized Design: Agilitech created a bespoke TFF system tailored to the manufacturer’s specific requirements, including the recommendation of a larger filter to manage increased biomaterial volumes and a robust pump capable of supporting potential future upscaling.
- Enhanced System Capabilities: The new system features higher flow rates, expedited production times, and increased automation, all of which aim to optimize operational efficiency.
- Brand-Agnostic Flexibility: One of the standout features of Agilitech’s solution is its brand-agnostic nature. This allows the manufacturer to source components from various suppliers, ensuring broader compatibility and resource optimization.
Implementation and Outcomes
- Front-End Planning and Design: Emphasis was placed on meticulous front-end planning and design to ensure the system was truly fit-for-purpose. This strategic approach led to a tailored solution that effectively met the company's specific needs and challenges.
- Positive Collaboration: The biologics manufacturer reported a highly positive experience working with Agilitech, noting their expertise, receptiveness, and willingness to tackle complex engineering challenges.
Key Takeaways
- Increased Throughput: The newly designed TFF system significantly increased biomaterial processing rates, alleviating workflow stress.
- Optimized Production: With higher flow rates and faster production times, the system allows for more efficient and scalable operations.
- Flexible Sourcing: Agilitech’s brand-agnostic approach ensures flexibility in sourcing components, which can be critical for customization and cost-effectiveness.
- Importance of Planning: Successful implementation underscored the necessity of front-end planning and individualized design for achieving a fit-for-purpose solution.
- Effective Partnership: The collaboration between the biologics manufacturer and Agilitech exemplified the benefits of working with a knowledgeable and proactive partner dedicated to addressing engineering challenges.
This case study demonstrates how strategic upgrades and a collaborative approach can lead to significant improvements in industrial processes, ultimately driving productivity and process optimization in biomanufacturing.